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Visfatin Peptide
Visfatin Peptide
- 中文名称：
- Visfatin Peptide
- 英文名称：
- Visfatin Peptide
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA76038
- 规格：
- 0.25 mg|2x0.25 mg|3x0.25 mg|4x0.25 mg|5x0.25 mg
- 保存建议：
- -20 degree C for long term storage
- 货期：
- 6-8周
- 纯度：
- N/A
- 产品形式：
- Antigenic Blocking Peptide
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
Visfatin (also known as Nicotinamide Phosphoribosyltransferase / NAMPT / Pre-B cell colony-enhancing factor / PBEF) is a ubiquitous 52 kDa adipokine secreted by adipose tissue. Visfatin is the rate-limiting component and intracellularly it acts as a cytosolic enzyme involved in the biosynthesis of nicotinamide adenine dinucleotide (NAD+, 1 ). Although it lacks a signal sequence, Visfatin is secreted by visceral adipose and functions as noncompetitive insulin mimetic and functions in the cytoplasm to regulate energy metabolism during stress responses, lowers blood glucose, improve insulin sensitivity and immune activation. Visfatin was first identified as a factor that enhanced the differentiation of B-cells. It is a secreted factor that is highly expressed in adipocytes. Visfatin is localized to the bloodstream and has various functions, including the promotion of vascular smooth muscle cell maturation and inhibition of neutrophil apoptosis. The protein is highly expressed in visceral fat and serum levels of the protein correlate with obesity and type 2 diabetes mellitus (2). Visfatin is expressed in large amounts in bone marrow, liver tissue, and muscle. It is also present in heart, placenta, lung, and kidney tissues. This gene has a pseudo gene on chromosome 10. Visfatin-selective antibodies were generated against ulJique N-terminal and C-terminal peptides characteristics of the human VISFATIN protein. FabGennix has generated highly specific rabbit VISFATIN polyclonal antibodies utilizing mostly N-terminal and C-terminal sequences. These antibodies have been fully characterized for cross reactivity with other cellular proteins. FabGennix has produced antibodies to multiple epitopes on the same protein that will facilitate studies utilizing interspecies cross reactivity. Western blot positive control samples in "ready-to-use" SDS-PAGE sample buffer and antigenic blocking peptide for Visfatin are available. The Visfatin positive control appears as a diffuse band around 60 kDa and co-migrates with rat adipocyte membrane Visfatin protein on a 10% SDS Page. All antibodies can be conjugated to fluorophores and other secondary enzymes as an additional service.
