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MOTS-c Peptide
MOTS-c Peptide
- 中文名称：
- MOTS-c Peptide
- 英文名称：
- MOTS-c Peptide
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA76019
- 规格：
- 0.25 mg|2x0.25 mg|3x0.25 mg|4x0.25 mg|5x0.25 mg
- 保存建议：
- Store at -20°C for long term storage
- 货期：
- 6-8周
- 纯度：
- N/A
- 产品形式：
- Two hundred and fifty micrograms (250ug) of peptide in 100ul of pH8.0 peptide buffer.
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
Overview: Mitochondria are functioning organelles that playa secondary role in signaling within the cell. While the details of mitochondrial signaling are not fully understood, the identification of an open reading frame in the mitochondrial DNA coding for humanin suggests that there are more signaling peptides coded by portions of the mtONA. A short open reading frame within the 12$ subunit of the mitochondrial ribosomal RNA codes for a 16 amino acid peptide called mitochondrial open reading frame of 125 rRNA-c, Of MOTS-c. MOTS-c plays a role in insulin sensitivity and metabolic homeostasis (1). MQTS-c targets skeletal muscle tissue, and the mechanism of its action involves inhibition of the folate cycle. MOTS-c promotes the formation of an endogenous AMP analog called 5-aminoimidazole4-carboxamide ribonucleotide (AICAR). AICAR is an activator of AMPK, suggesting that MOTS-c could be used in an insulin-regulation capacity in order to treat type 2 diabetes (2).
MOTS-c selective antibodies were generated against a peptide taken from the human protein. The MOTS--c· selective antibodies are affinity purified on an immobilized antigen based affinity matrix, the isolated antibodies were then stabilized in antibody stabilization buffer for long-term storage. The MOTS-c-selective antibodies are fully characterized for applications in western blotting and ELISA at the recommended dilutions.
