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ACE2 (SARS Receptor) Antibody (C-term) Blocking Peptide
ACE2 (SARS Receptor) Antibody (C-term) Blocking Peptide
- 中文名称：
- ACE2 (SARS Receptor) Antibody (C-term) Blocking Peptide
- 英文名称：
- ACE2 (SARS Receptor) Antibody (C-term) Blocking Peptide
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA290798
- 规格：
- 0.5 mg|2x0.5 mg|3x0.5 mg|4x0.5 mg|5x0.5 mg
- 保存建议：
- Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
- 货期：
- 6-8周
- 纯度：
- N/A
- 产品形式：
- The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze apelin- 13 and dynorphin-13 with high efficiency. May be an important regulator of heart function. In case of human coronaviruses SARS and HCoV-NL63 infections, serve as functional receptor for the spike glycoprotein of both coronaviruses.
Background:
ACE2 cDNA encodes a deduced 805-amino acid protein containing a potential 17-amino acid N-Terminal signal peptide and a putative 22-amino acid C-Terminal membrane anchor. It also possesses a zinc metalloprotease consensus sequence and a conserved glutamine residue that may function as a third zinc ligand. ACE2 is expressed predominantly in vascular endothelial cells of the heart and kidney. ACE converts angiotensin l to angiotensin ll, ACE2 converts angiotensin l to angiotensin 1-9, which has 9 amino acids. Angiotensin ll is a potent blood vessel constrictor, while angiotensin 1-9 does not impact blood vessels but is cleaved by ACE to a shorter peptide, angiotensin 1-7, which is a blood vessel dilator. Spike proteins of coronaviruses, including the SARS coronavirus. Bind with cellular receptors to mediate infection of target cells. ACE2 binds the S1 domain of the SARS coronavirus S protein. SARS coronavirus replicates efficiently on ACE2-Transfected but not mock-transfected 293T cells. Anti-ACE2 but not anti-ACE1 antibody blocks viral replication on Vero E6 cells. It has been proposed the ACE2 is a functional receptor of SARS coronavirus.
