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PCSK9 Antibody (C-term) Blocking Peptide
PCSK9 Antibody (C-term) Blocking Peptide
- 中文名称：
- PCSK9 Antibody (C-term) Blocking Peptide
- 英文名称：
- PCSK9 Antibody (C-term) Blocking Peptide
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA290807
- 规格：
- 0.5 mg|2x0.5 mg|3x0.5 mg|4x0.5 mg|5x0.5 mg
- 保存建议：
- Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
- 货期：
- 6-8周
- 纯度：
- N/A
- 产品形式：
- Peptides are lyophilized in a solid powderformat. Peptides can be reconstituted insolution using the appropriate buffer asneeded.
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
Background: PCSK9 is a proprotein convertase belonging tothe proteinase K subfamily of the secretorysubtilase family. This protein is synthesized asa soluble zymogen that undergoesautocatalytic intramolecular processing in theendoplasmic reticulum. The protein mayfunction as a proprotein convertase. Theprotein plays a role in cholesterol homeostasisand may have a role in the differentiation ofcortical neurons.
Function: Crucial player in the regulation of plasma cholesterol homeostasis. Binds to low-density lipid receptor family members: low density lipoprotein receptor (LDLR), very low density lipoprotein receptor (VLDLR), apolipoprotein E receptor (LRP1/APOER) and apolipoprotein receptor 2 (LRP8/APOER2), and promotes their degradation in intracellular acidic compartments. Acts via a non-proteolytic mechanism to enhance the degradation of the hepatic LDLR through a clathrin LDLRAP1/ARH-mediated pathway. May prevent the recycling of LDLR from endosomes to the cell surface or direct it to lysosomes for degradation. Can induce ubiquitination of LDLR leading to its subsequent degradation. Inhibits intracellular degradation of APOB via the autophagosome/lysosome pathway in a LDLR-independent manner. Involved in the disposal of non-acetylated intermediates of BACE1 in the early secretory pathway. Inhibits epithelial Na(+) channel (ENaC)-mediated Na(+) absorption by reducing ENaC surface expression primarily by increasing its proteasomal degradation. Regulates neuronal apoptosis via modulation of LRP8/APOER2 levels and related anti-apoptotic signaling pathways.
