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Sulf2
Sulf2
- 中文名称：
- Sulf2
- 英文名称：
- Sulf2
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA60513
- 规格：
- 0.05 mg|2x0.05 mg|3x0.05 mg|4x0.05 mg|5x0.05 mg
- 保存建议：
- Product should be stored at -20 degree C. Aliquot to avoid freeze/thaw cycles
Products are stable for one year frompurchase when stored properly.
- 货期：
- 6-8周
- 纯度：
- N/A
- 产品形式：
- Provided as solution in phosphate buffered saline with 0.08% sodium azide
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
Sulf-2 exhibits arylsulfatase activity and highly specific endoglucosamine -6-sulfatase activity. It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin.
Heparan sulfate proteoglycans act as co-receptors for numerous heparinbinding growth factors and cytokines and are key regulators of cell signaling. Growth factor binding to heparan sulfate results in mitogenic activity only when specific structural features are present within the heparan sulfate chains. These features include sulfation at specific positions within a disaccharide (N, 2-O, 3-O, 6-O) by the enzymes that regulate heparan sulfate synthesis inside the Golgi. Following synthesis and expression, heparan sulfate can be structurally and functionally modified within the extracellular compartment. Enzymes known to have these effects are heparanase, which cleaves heparan sulfate chains into smaller biologically active fragments, and the heparan sulfate 6-Oendosulfatases (Sulfs). The Sulfs represent a new and novel family of enzymes that are secreted via the Golgi and subsequently localized to the cell surface or may be released into the extracellular matrix. Sulf-1 enzyme is required for Wnt-mediated signaling in developing quail muscle. Sulf1 was shown (in quial) to restore bone morphogenetic protein signaling in cells by releasing the functional inhibitor, Noggin, from cell surfaces. Quail Sulf1 can also inhibit growth factor signaling, the removal of the 6-O-sulfation is required for the formation of the FGF HS FR1c ternary complex blocking FGF2 signaling.
Analysis of human tumor tissue and tumor cell lines suggests that HSulf-1 is misregulated in cancers. HSulf-1 is found in a variety of normal tissues but is down-regulated in tumor cell lines originating from ovarian, breast, pancreatic, renal, and hepatocellular carcinoma.
