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2019-nCoV NSP10/NSP16 Methyltransferase, Active
2019-nCoV NSP10/NSP16 Methyltransferase, Active
- 中文名称：
- 2019-nCoV NSP10/NSP16 Methyltransferase, Active
- 英文名称：
- 2019-nCoV NSP10/NSP16 Methyltransferase, Active
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA73168
- 规格：
- 0.01 mg|0.02 mg|0.05 mg|2x0.05 mg|3x0.05 mg
- 保存建议：
- Store product at -70 degree C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
- 货期：
- 6-8周
- 纯度：
- N/A
- 产品形式：
- 50mM sodium phosphate, pH7.0, 300mM NaCl, 150mM imidazole, 0.25mM DTT, 25% glycerol
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
Recombinant 2019-nCoV NSP10/NSP16 methyltransferase includes full length NSP10 (A4254-Q4392) and NSP16 (S6799-N7096) expressed in E Coli using C-terminal His tag.
Overview: Many eukaryotic viruses have evolved 2'-O-methyltransferases (2'-O-MTase) to modify their viral mRNAs and carry a cap-1 structure (m7GpppNm) at the 5' end. This 5' cap structure is important for viral mRNA stability, protein translation and viral immune escape (1). SARS-CoV possess NSP16 that has 2'-O-MTase activity. NSP16 requires NSP 10 for activation which is a conserved mechanism in corona viruses (2). Therefore, inhibitors targeting the NSP10/NSP16 2'-O-MTase are potential targets for developing anti-Corona virus drugs (3).
