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2019-nCoV NSP14 Methyltransferase, Active
2019-nCoV NSP14 Methyltransferase, Active
- 中文名称：
- 2019-nCoV NSP14 Methyltransferase, Active
- 英文名称：
- 2019-nCoV NSP14 Methyltransferase, Active
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA73169
- 规格：
- 0.01 mg|0.02 mg|0.05 mg|2x0.05 mg|3x0.05 mg
- 保存建议：
- Store product at -70 degree C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at the recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
- 货期：
- 6-8周
- 纯度：
- N/A
- 产品形式：
- Recombinant protein stored in 50mM sodium phosphate, pH7.0, 300mM NaCl, 150mM imidazole, 0.25mM DTT, 25% glycerol
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
Recombinant SARS-CoV-2 (COVID-19) NSP14 Methyltransferase (5925-6452) was expressed in E Coli using a C-terminal His-tag.
Overview: Corona viruses codes for a bifunctional non-structural protein 14 (NSP14) that is important for viral replication and transcription. NSP14 contains an N-terminal exo-ribonuclease (ExoN) domain for proof reading during viral replication and a C-terminal N-7 methyltransferase (N7-MTase) domain for mRNA capping. NSP14 associates with several viral proteins (1). It can bind to NSP10 and the resulting complex exhibits enhanced ExoN activity in vitro (2). It can also bind to the polymerase complex (NSP12/NSP8/NSP7) forming a complex that retains all associated enzymatic activities (3).
