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Anti-Survival Motor Neuron (SMN) Antibody
Anti-Survival Motor Neuron (SMN) Antibody
- 中文名称：
- Anti-Survival Motor Neuron (SMN) Antibody
- 英文名称：
- Anti-Survival Motor Neuron (SMN) Antibody
- 品牌：
- phosphosolutions
- 品牌介绍：
- PhosphoSolutions公司成立于2001年。Michael D. Browning, John W. Haycock和Andrew J. Czernik，他们都在Paul Greengard博士的实验室工作过，Paul Greengard博士是2000年诺贝尔医学奖的共同获得者因为他在神经系统信号转导中蛋白质磷酸化的作用。这一专业知识使我们主要关注神经科学领域感兴趣的蛋白质。
- 货号：
- 1904-SMNt
- 规格：
- 25 µL
- 保存建议：
- Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.
- 背景资料：
- Survival Motor Neuron (SMN) protein, also known as Gemin1, is derived from the SMN gene which has two nearly identical copies located on chromosome 5q13, SMN1 and SMN2 (Lefebvre et al, 1995). SMA, Spinal Muscular Atrophy, is a neurodegenerative disease caused by mutations of the SMN gene that result in a loss of motor neurons and subsequent progressive limb and trunk muscular atrophy and paralysis (Crawford et al, 1996). SMN1 produces functional, full-length SMN protein, while SMN2 encodes a truncated form of SMN protein that is unstable and defective (Wolstencroft et al., 2005). SMN2 plays a key role in the development of SMA in that the number of SMN2 copies modulates disease severity (Monani et al, 2000). The SMN protein is expressed ubiquitously and found in the cytoplasm as well as nuclear Cajal bodies (Young et al, 2000).
- 货期：
- 3-4周
- 来源宿主：
- Mouse
- 反应种属：
- Human, Mouse, and Rat
- 应用：
- ELISA, WB, ICC
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 其他：
浓度:1 mg/ml
推荐稀释比（WB）:1:4000
推荐稀释比（ICC）:1:50-1:500
- 说明书：
Our Anti-Survival Motor Neuron (SMN) mouse monoclonal primary antibody from PhosphoSolutions is produced in-house. It detects human, mouse, and rat Survival Motor Neuron (SMN) and is Protein G purified. It is great for use in WB, ICC.
