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Anti-TDP43 Antibody
Anti-TDP43 Antibody
- 中文名称：
- Anti-TDP43 Antibody
- 英文名称：
- Anti-TDP43 Antibody
- 品牌：
- phosphosolutions
- 品牌介绍：
- PhosphoSolutions公司成立于2001年。Michael D. Browning, John W. Haycock和Andrew J. Czernik，他们都在Paul Greengard博士的实验室工作过，Paul Greengard博士是2000年诺贝尔医学奖的共同获得者因为他在神经系统信号转导中蛋白质磷酸化的作用。这一专业知识使我们主要关注神经科学领域感兴趣的蛋白质。
- 货号：
- 2000-TDPt
- 规格：
- 25 µL
- 保存建议：
- Recommended that the undiluted antibody be aliquoted into smaller working volumes (10-30 uL/vial depending on usage) upon arrival and stored long term at -20° C or -80° C, while keeping a working aliquot stored at 4° C for short term. Avoid freeze/thaw cycles. Stable for at least 1 year.
- 背景资料：
- TDP43 (Tar DNA Binding 43, TARDBP) was originally identified as a protein which binds to the "transactivation response" (TAR) sequence found in the long terminal repeat of the HIV-1 virus genome (Ou et al.,1995). UV cross-linking of HeLa cell extract revealed a 43kDa protein which was cloned and sequenced and shown to contain two copies of the ~90 amino acid RRM domain. RRM is an acronym for RNA Recognition Motif, and this domain is found in many proteins which bind single stranded RNA and some which bind single stranded DNA. Northern blots showed that the protein is ubiquitous in tissue expression. Much interest has been focused on TDP43 recently due to its association with the inclusions seen in frontotemporal lobar degeneration and Amyotrophic Lateral Sclerosis (Neumann et al., 2006). The protein is present in these inclusions in partially degraded, hyperphosphorylated and ubiquitinated forms.
- 货期：
- 3-4周
- 来源宿主：
- Rabbit
- 反应种属：
- Human and Rat
- 应用：
- ELISA, WB, IHC, ICC
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 其他：
浓度:0.8 mg/ml
推荐稀释比（WB）:1:1000
推荐稀释比（WB Brain）:1:1000
推荐稀释比（IHC）:1:250-1:1000
推荐稀释比（ICC）:1:1000
- 说明书：
Our Anti-TDP43 primary antibody from PhosphoSolutions is rabbit polyclonal. It detects human and rat TDP43 and is affinity purified. It is great for use in WB, IHC, ICC.
