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Anti-Ubiquitin C-terminal Hydrolase 1 (UCHL1) Antibody
Anti-Ubiquitin C-terminal Hydrolase 1 (UCHL1) Antibody
- 中文名称：
- Anti-Ubiquitin C-terminal Hydrolase 1 (UCHL1) Antibody
- 英文名称：
- Anti-Ubiquitin C-terminal Hydrolase 1 (UCHL1) Antibody
- 品牌：
- phosphosolutions
- 品牌介绍：
- PhosphoSolutions公司成立于2001年。Michael D. Browning, John W. Haycock和Andrew J. Czernik，他们都在Paul Greengard博士的实验室工作过，Paul Greengard博士是2000年诺贝尔医学奖的共同获得者因为他在神经系统信号转导中蛋白质磷酸化的作用。这一专业知识使我们主要关注神经科学领域感兴趣的蛋白质。
- 货号：
- 2060-UCHL1t
- 规格：
- 25 µL
- 保存建议：
- Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.
- 背景资料：
- Ubiquitin C-terminal hydrolase 1 (UCHL1) is also known as ubiquitin carboxyl esterase L1, ubiquitin thiolesterase, neuron-specific protein PGP9.5 and Park5. It was originally identified as a major component of the neuronal cytoplasm from 2-dimensional gel analysis of brain tissues, and was given the name PGP9.5 (1). It was later found that ubiquitin C-terminal hydrolase enzyme activity was associated with the PGP9.5 protein (2). The ubiquitin C-terminal hydrolases cleave ubiquitin from other molecules. Regulation of the ubiquitin pathway is very important and many disease states are associated with defects in this pathway. Genetic knockout of UCHL1 in mice results in a motor neuron degeneration similar to the spontaneous gracile axonal dystrophy (gad) mutant mice (3). Point mutations in the UCHL1 gene are associated with some forms of human Parkinson's disease (4). Since UCHL1 is heavily expressed in neurons, it is released in large amounts following injury or degeneration, so the detection of UCHL1 in CSF and other bodily fluids can be used as a biomarker.
- 货期：
- 3-4周
- 来源宿主：
- Mouse
- 反应种属：
- Bovine, Human, Mouse, Pig, and Rat
- 应用：
- ELISA, WB, IHC, ICC
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 其他：
浓度:1 mg/ml
推荐稀释比（WB）:1:5000
推荐稀释比（WB Brain）:1:5000
推荐稀释比（IHC）:1:500-1:5000
推荐稀释比（ICC）:1:500-1:2000
- 说明书：
Our Anti-Ubiquitin C-terminal Hydrolase 1 (UCHL1) primary antibody from PhosphoSolutions is mouse monoclonal. It detects bovine, human, mouse, pig, and rat Ubiquitin C-terminal Hydrolase 1 (UCHL1) and is Protein G purified. It is great for use in WB, IHC, ICC.
