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Anti-Xin Actin-binding Repeat-containing Protein 1 (XIRP1) (Ser295) Antibody
Anti-Xin Actin-binding Repeat-containing Protein 1 (XIRP1) (Ser295) Antibody
- 中文名称：
- Anti-Xin Actin-binding Repeat-containing Protein 1 (XIRP1) (Ser295) Antibody
- 英文名称：
- Anti-Xin Actin-binding Repeat-containing Protein 1 (XIRP1) (Ser295) Antibody
- 品牌：
- phosphosolutions
- 品牌介绍：
- PhosphoSolutions公司成立于2001年。Michael D. Browning, John W. Haycock和Andrew J. Czernik，他们都在Paul Greengard博士的实验室工作过，Paul Greengard博士是2000年诺贝尔医学奖的共同获得者因为他在神经系统信号转导中蛋白质磷酸化的作用。这一专业知识使我们主要关注神经科学领域感兴趣的蛋白质。
- 货号：
- p2400-295t
- 规格：
- 25 µL
- 保存建议：
- Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.
- 背景资料：
- XIRP1 is a member of the Xin family of proteins, containing 16 Xin repeats. The intercalated disk protein Xin protects actin filaments from depolymerization, and is able to bundle actin filaments to interact with β-catenin, which is thought to stabilize actin-based cytoskeletons (Choi et al., 2007). The evolutionary emergence of the Xin paralogs may have played a key role in the development of heart chambers with complete endothelial and myocardial layers (Grosskurth et al., 2008). Loss of mXina (mouse Xin homolog) results in cardiac hypertrophy and cardiomyopathy (Gustafson-Wagner et al., 2007). Phosphorylation of Ser-295 plays a key role in XIRP1 signaling, and therefore in cardiac hypertrophy, as it has been shown that acute pressure-overloaded hearts rapidly increased phosphorylation at the Ser-295 residue of XIRP1. (Chang et al., 2013).
- 货期：
- 3-4周
- 来源宿主：
- Rabbit
- 反应种属：
- Mouse
- 应用：
- ELISA, WB
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 其他：
浓度:Lot Dependent
推荐稀释比（WB）:1:1000
- 说明书：
Our Anti-Xin Actin-binding Repeat-containing Protein 1 (XIRP1) (Ser295) rabbit polyclonal phosphospecific primary antibody from PhosphoSolutions is produced in-house. It detects mouse Xin Actin-binding Repeat-containing Protein 1 (XIRP1) (Ser295) and is antigen affinity purified from pooled serum. It is great for use in WB.
