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PGP9.5/UCHL1
PGP9.5/UCHL1
- 中文名称：
- PGP9.5/UCHL1
- 英文名称：
- PGP9.5/UCHL1
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA76716
- 规格：
- 0.1 mL|2x0.1 mL|3x0.1 mL|4x0.1 mL|5x0.1 mL
- 保存建议：
- The antibody can be stored at 2 degree - 8 degree C for 12 month without detectable loss of activity. Avoidrepeated freeze-thaw cycles.
- 货期：
- 6-8周
- 来源宿主：
- Chicken
- 反应种属：
- Human, Mouse, Rat, Bovine, Porcine, Equine
- 应用：
- IF (Immunofluorescence), IHC (Immunohistochemistry), WB (Western Blot), ICC (Immunocytochemistry)
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 其他：
克隆性:Polyclonal
同型:Chicken IgY
克隆号:N/A
特异性:N/A
纯度:N/A
形式：Liquid. Supplied as an aliquot of IgYpreparation plus 5mM NaN3
浓度：N/A
- 说明书：
Ubiquitin C-terminal hydrolase 1 (UCHL1) is an extremely abundant protein of brain, where it is localized only in neurons. It was originally named PGP9.5 and discovered as a major protein spot on 2D gels of brain extracts which was absent on similar gels of other tissues. Later it was found that the PGP9.5 protein was an enzyme which could cleave ubiquitin monomers from ubiquitin conjugates and polyubiquitin chains, resulting in recycling of ubiquitin monomers and the renaming of PGP9.5 to UCHL1 to reflect this enzymatic activity. UCHL1 is an essential enzyme and defects in UCHL1 protein expression are involved in Parkinson's disease (PD) and other more serious disease states. In addition, UCHL1 may be released into cerebrospinal fluid (CSF) and blood following CNS damage and disease resulting in neuronal loss.
This antibody was made against full length recombinant human UCHL1 expressed in and purified from E coli and can be used to identify neurons and their processes in culture or in sections. The antibody works cleanly on appropriate lysates of cell and tissues. Considerable interest has been focused on the detection of UCHL1 in the blood and CSF of patients with traumatic injuries to the brain or spinal cord. This antibody has been widely used as both a capture and a detection reagent in ELISA type assays for measuring UCHL1 levels in blood and CSF samples.
