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CXCR3 Antibody Antigenic Blocking Peptide
CXCR3 Antibody Antigenic Blocking Peptide
- 中文名称：
- CXCR3 Antibody Antigenic Blocking Peptide
- 英文名称：
- CXCR3 Antibody Antigenic Blocking Peptide
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA75992
- 规格：
- 0.25 mg|2x0.25 mg|3x0.25 mg|4x0.25 mg|5x0.25 mg
- 保存建议：
- -20 degree C for long term storage
- 货期：
- 6-8周
- 纯度：
- N/A
- 产品形式：
- Antigenic Blocking Peptide
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
Background: Chemokines (Chemoattractant Cytokines) are small peptides that are potent activators and chemo-attractants for leukocyte subpopulations and other non-hematopoietic cells. Chemokine receptors (CXCR) belong to the super-family of G protein-coupled receptors (GPCR), which regulate the trafficking and activation of leukocytes, and operate as co-receptors in the entry of HIV-1 and proliferation and migration of immature neurons, glia and their precursors. Furthermore, chemokine receptors participate in the etiology and progression of various brain disorders, including AIDS dementia, neuro-inflammatory disease and neuroplasia, making them important potential therapeutic targets in these cases.
Activation of naYve T cells by specific antigen and cytokines, up-regulate cell adhesion molecules (CAM) as well as chemokine receptors on their surface, which directs them to migrate towards the inflamed tissues. The CXCR3 receptor protein is approximately 40-45 koa protein which has 7 transmembrane domains, characteristic of G-protein coupled receptors. The protein has putative N-glycosylation sites near the extracellular N-terminal end of the protein. The protein has a large 3rd intracellular loop which interacts with G-proteins. The short carboxy terminal is intracellular and has putative post-translational sites.
The Anti-CXCR3h-selective antibodies were generated against unique peptide sequence from the CXCR3 receptors gene that is expressed only in a CXCR3 receptor subtype of the human protein. The polyclonal antibodies were affinity purified on an immobilized antigen based affinity chromatography. Antigenic blocking peptides (please inquire) and western blot positive control (please inquire) in ready to use SoS-sample buffers are available. Antibodies can be conjugated to fluorophores and other seconda ry enzymes upon request at nominal cost. MBS, Inc. also provides antibodies against several other GPCRs including orphan receptors.
