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Anti-PAK-1 (Thr84) Antibody
Anti-PAK-1 (Thr84) Antibody
- 中文名称：
- Anti-PAK-1 (Thr84) Antibody
- 英文名称：
- Anti-PAK-1 (Thr84) Antibody
- 品牌：
- phosphosolutions
- 品牌介绍：
- PhosphoSolutions公司成立于2001年。Michael D. Browning, John W. Haycock和Andrew J. Czernik，他们都在Paul Greengard博士的实验室工作过，Paul Greengard博士是2000年诺贝尔医学奖的共同获得者因为他在神经系统信号转导中蛋白质磷酸化的作用。这一专业知识使我们主要关注神经科学领域感兴趣的蛋白质。
- 货号：
- p187-84t
- 规格：
- 25 µL
- 保存建议：
- Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.
- 背景资料：
- PAKs, p21 activated kinases, are a family of serine/threonine protein kinases comprised of six isoforms, PAK1-6, and they play important roles in cytoskeleton dynamics, cell survival and proliferation (Ye et al, 2012). Each of these isoforms contains a C-terminal catalytic domain and an N-terminal regulatory domain with a small G protein binding motif (Chen et al, 2004). OSR1, oxidative stress response 1, is activated only by osmotic stresses, like sorbital or NaCl (Chen et al, 2004). It has been predicted that OSR1 phosphorylates PAK1 in the regulatory domain at thr84 and inhibits activation of JNK and MAPK pathway. (Chen et al, 2004). It has also been suggested that OSR1 may have a regulating function with actin cytoskeleton because it can phosphorylate PAK1 at Thr-84 and bind to gelsolin (Chen et al, 2004).
- 货期：
- 3-4周
- 来源宿主：
- Rabbit
- 反应种属：
- Human, Mouse, and Rat
- 应用：
- ELISA, WB
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 其他：
浓度:Lot Dependent
推荐稀释比（WB）:1:1000
推荐稀释比（WB Brain）:1:1000
- 说明书：
Our Anti-PAK-1 (Thr84) rabbit polyclonal phosphospecific primary antibody from PhosphoSolutions is produced in-house. It detects human, mouse, and rat PAK-1 (Thr84) and is antigen affinity purified from pooled serum. It is great for use in WB.
